Targeting Buckyballs with Antibodies

 
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Buckyballs
View previous topic :: View next topic  
Author Message
nanoorg
Site Admin


Joined: 16 Mar 2004
Posts: 1392

PostPosted: Mon Nov 27, 2006 12:43 pm    Post subject: Targeting Buckyballs with Antibodies Reply with quote

Targeting Buckyballs with Antibodies


Hollow buckyballs, spherical molecules made of sixty carbon atoms linked to one another like the panels of a soccer ball, have the potential to ferry large doses of anticancer drugs or imaging agents to tumors. A new method for attaching tumor-targeting antibodies to the surface of buckyballs could help turn this promise into reality.

Writing in the journal Chemical Communications, a research team headed by Lon Wilson, Ph.D., of Rice University, describes the chemical methods it developed to turn water-soluble fullerenes – the scientific name for buckyballs – into antibody-linked cargo containers for drugs and imaging agents. As a proof-of-principle, the researchers used an antibody that binds to protein found on the surface of melanoma cells. The investigators characterized the binding behavior of the resulting molecular combo, showing that the method they used to attach fullerenes to antibodies does not affect the ability of the antibodies to bind to their biological target, which presumably would be on the surface of cancer cells.

The researchers also found that they were able to attach as many as 15 fullerenes to a single antibody without changing the antibody’s target-binding properties. They note that the ability to attach multiple fullerenes to a single antibody could lead to the creation of multifunctional nanoscale devices that could deliver imaging agents and combinations of drugs to tumors.



http://nano.cancer.gov/


This story was first posted on 6th September 2006.
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Buckyballs All times are GMT
Page 1 of 1
 

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2002 phpBB Group