Nanoparticle-Drug Stops Tumor-Associated Angiogenesis

 
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed
View previous topic :: View next topic  
Author Message
nanoorg
Site Admin


Joined: 16 Mar 2004
Posts: 1392

PostPosted: Tue Oct 10, 2006 3:21 pm    Post subject: Nanoparticle-Drug Stops Tumor-Associated Angiogenesis Reply with quote

Encapsulated Nanoparticle-Drug Stops Tumor-Associated Angiogenesis


By encapsulating a drug already approved to treat a side effect of cancer inside liposomal nanoparticles, researchers at the University of Zürich have developed an agent that stops tumor-associated angiogenesis and reduces tumor growth by as much as 92 percent.

This new potential anticancer agent works by depleting the number of a specific type of immune system cell thought to be associated with tumor growth and metastasis. This work appears in the British Journal of Cancer.

Reto Schwendener, Ph.D., and colleagues developed a liposomal formulation of the drug clodronate to target tumor-associated macrophages, immune system cells that actually promote tumor growth and angiogenesis. Research had already demonstrated that clodronate, a drug now used to inhibit bone shrinkage that can occur in cancer patients, can inhibit angiogenesis, and tests with cultured tumor-associated macrophages showed that liposomal clodronate was toxic to these particular cells.

Using a mouse model of human rhabdomyosarcoma, a malignant tumor of muscles, the investigators found that liposomal clodronate drastically reduced the density of blood vessels in tumors, depleted tumor-associated macrophages, and markedly reduced tumor growth. Antitumor activity was even more pronounced when this new agent was administered with antibodies that bind to vascular endothelial growth factor (VEGF), a molecule that triggers new blood growth. This study did find, however, that treatment was not able to fully suppress tumor growth and noted that this therapy would therefore be useful only in combination with other forms of chemotherapy, as is true with other anti-angiogenesis agents.




Source:
http://nano.cancer.gov/




This story was first posted on 8th August 2006.
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed All times are GMT
Page 1 of 1
 

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2002 phpBB Group