‘Demultiplexer’ Analyses Signals from Molecular Sensors

 
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanosensors
View previous topic :: View next topic  
Author Message
grantnano
Site Admin


Joined: 03 Oct 2005
Posts: 432

PostPosted: Thu Oct 20, 2005 12:42 pm    Post subject: ‘Demultiplexer’ Analyses Signals from Molecular Sensors Reply with quote

Caltech Scientists Build a ‘Demultiplexer’ to Analyse Signals from Nanowire-Based Molecular Sensors

As researchers develop methods for creating nanowire-based molecular sensors capable of detecting hundreds of biomarkers simultaneously, they will also need new techniques for analyzing the complex signals that such sensors will generate when they are testing complex biological samples. A team of investigators at the California Institute of Technology has now developed one possible method for making sense out of such data-rich signals and has verified that this approach works on an array that includes 150 nanowires.

Writing in the journal Science, James Heath, Ph.D., and his colleagues at Caltech describe their approach to "demultiplexing" the signals from ultrahigh-density nanowire circuits. Demultiplexing refers to the ability to electrically address, or get data from, large numbers of individual nanowires using many fewer electrical connectors. This is a particular challenge given that nanowire assemblies are often characterized by defects and some randomness in the way that the wires are organized in circuits.

To build their demultiplexer, Dr. Heath, who is a principle investigator of one of the NCI's Centers of Cancer Nanotechnology Excellence, and his collaborators used standard lithographic techniques to deposit pairs of conducting metal lines perpendicular to the nanowires, which all run parallel to each other like the strings in a piano. By passing an electrical current through the pairs, and varying which pairs are powered, the researchers are able to address an individual nanowire and determine its electrical status. For example, nanowires coated with a tumor biomarker detection reagent, such as an aptamer or antibody, display sharp changes in electrical behavior when those reagents bind to the biomarker they are designed to detect.

This work is detailed in a paper titled, "Bridging dimensions: demultiplexing ultrahigh-density nanowire circuits." This paper was published online in advance of print publication. An abstract is available through PubMed.

Source: NCI Alliance for Nanotechnology in Cancer.

URL: http://nano.cancer.gov/news_center/nanotech_news_2005-10-17d.asp
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanosensors All times are GMT
Page 1 of 1
 

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2002 phpBB Group