Researchers Use Silver-Based Dendrimers for Bio-Labelling

 
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed
View previous topic :: View next topic  
Author Message
grantnano
Site Admin


Joined: 03 Oct 2005
Posts: 432

PostPosted: Wed Nov 02, 2005 1:42 pm    Post subject: Researchers Use Silver-Based Dendrimers for Bio-Labelling Reply with quote

Researchers Develop Silver-Containing Dendrimers that Can Label Individual Biomolecules Inside Cells

Nanoscale dendrimers, a type of spherical polymer, have shown promise as multifunctional delivery agents for anticancer drugs and imaging agents. Now, investigators at the University of Michigan and the Roswell Park Cancer Institute have developed silver-containing dendrimers that can function as non-toxic intracellular molecular beacons that should be capable of labeling individual biomolecules within a cell.

Reporting its work in the journal Nano Letters, a team led by Lajos Balogh, Ph.D., of the Roswell Park Cancer Center, and James Baker Jr., M.D., of the University of Michigan, describe how they construct dendrimer nanoparticles with diameters ranging from 3 to 7 nanometers, each loaded with 25 atoms of silver. The silver atoms, trapped within the branches of the dendrimer, fluoresce with sufficient brightness that a single silver-loaded dendrimer nanoparticle can be positioned accurately within a cell using a standard confocal fluorescence microscope.

In vitro assays showed that the surface properties of the new materials played a significant role in determining if the dendrimer-silver nanocomposites were toxic to cells. The results were identical to those obtained using the analogous dendrimers that did not contain silver, and the investigators noted that this was the first demonstration that the biological properties of a dendrimer nanocomposite were determined by the dendrimer. In their paper, the researchers also present data on the physical characterization of four different dendrimer-silver nanocomposites.

This work is detailed in a paper titled, “Silver/dendrimer nanocomposites as biomarkers: fabrication, characterization, in vitro toxicity, and intracellular detection.” This paper was published online in advance of print publication. An abstract is available through the journal’s website.

Source: NCI Alliance for Nanotechnology in Cancer.

URL: http://nano.cancer.gov/news_center/nanotech_news_2005-10-31b.asp

This story was posted on 1 November 2005.
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed All times are GMT
Page 1 of 1
 

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2002 phpBB Group