Using Nanoparticles to Show Drug Delivery into the Brain

 
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed
View previous topic :: View next topic  
Author Message
grantnano
Site Admin


Joined: 03 Oct 2005
Posts: 432

PostPosted: Wed Jan 11, 2006 10:15 am    Post subject: Using Nanoparticles to Show Drug Delivery into the Brain Reply with quote

Scientists at University of California Use Nanoparticles to Show Drug Delivery into the Brain

At the boundary between the brain and the body lies a tightly knit set of cells, known as the blood-brain barrier, that helps protect the brain from infection or exposure to potentially harmful molecules. Unfortunately, the blood-brain barrier also blocks most anticancer drugs from entering the brain, making it difficult to treat brain cancer and spurring researchers to search for methods of breaching the blood-brain barrier without damaging it. One such technique, known as convention-enhanced delivery, or CED, has shown initial promise in human clinical studies, and investigators are now attempting to improve this method.

To help these efforts, a group of investigators led by Krystof Bankiewicz, M.D., and Tracy McKnight, Ph.D., at the University of California, San Francisco (UCSF), has turned to nanoparticles in order to visualize how drug travels through the brain when administered using CED. In a paper published in the journal Experimental Neurology, the UCSF team shows how liposomes loaded with gadolinium can provide detailed magnetic resonance images of drug moving through a living primate brain following CED.

The investigators tracked the distribution of gadolinium-containing liposomes using real-time magnetic resonance imaging (MRI). Liposomes were detected in targeted brain regions between 10 to 20 minutes following injection. The investigators note that the MR images were highly accurate at determining tissue distribution. Based on the results of their experiments in non-human primates, the researchers conclude that nanoparticle technology combined with MRI and CED may provide new opportunities for treating human brain tumors.

This work, funded in part by the National Cancer Institute, is detailed in a paper titled, “Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain.” An abstract is available through PubMed.

Source: NCI Alliance for Nanotechnology in Cancer.

URL: http://nano.cancer.gov/news_center/nanotech_news_2006-01-09b.asp

This story was posted on 10 January 2006.
Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    Institute of Nanotechnology Forum Index -> Nanobiomed All times are GMT
Page 1 of 1
 

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2002 phpBB Group