Fluorescent Nanostring Barcodes Transform Diagnostics

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PostPosted: Wed May 13, 2009 10:09 am    Post subject: Fluorescent Nanostring Barcodes Transform Diagnostics Reply with quote

A new technology with research and clinical application, including the early detection of disease, has been conceived and developed by University of Queensland researchers.

Dr Krassen Dimitrov, from UQ's Australian Institute for Bioengineering & Nanotechnology, has developed fluorescent “barcodes” called nanostrings, which offer greater sensitivity and accuracy than current detection methods.

The research has been published in Nature Biotechnology ( "Direct multiplexed measurement of gene expression with color-coded probe pairs" ).

Dr Dimitrov said nanostrings bind to RNA molecules for digital gene expression analysis.

RNA molecule
Image credit: http://www.mse.ncsu.edu/yingling/Research.html

“Because this system can count the exact number of biomolecules present, we can get an extremely accurate and sensitive picture of gene expression at a particular point in time,” Dr Dimitrov said.

“This quantitative data is superior to other gene expression systems such as microarrays, which rely on the analogue measurement of fluorescence and therefore are less accurate and have a limited range.

“The nanostring is an important technological development in both clinical and research settings. We will be able to more accurately detect molecules associated with particular diseases, and in the research arena we will be able to identify new molecules associated with diseases and trace these back to the genes responsible."

He said the technology is based on a non-enzymatic process which reduces the chance of bias and is more robust in a variety of different conditions.

Dr Dimitrov is currently working on the next step, which will be new nano-barcodes that will further reduce the cost and improve sensitivity and usability.

This technology has been commercialised in Seattle by a company founded by Dr Dimitrov in 2003.

The AIBN is a multi-disciplinary research institute based at UQ, which brings together the skills of world-class researchers in the areas of bioengineering and nanotechnology to produce positive health and environmental outcomes such as biomedical delivery; bio-devices; tissue regeneration; and cell therapies.

Sources: http://www.uq.edu.au/news/index.html?article=14763
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