Carbon Black Nanoparticles Kill Cells
Researchers from the University of Iowa Roy J. and Lucille A. Carver College of Medicine have found that inhaled carbon black nanoparticles create a double source of inflammation in the lungs.
Their findings were published online in the April 27 edition of the Journal of Biological Chemistry. Martha Monick, Ph.D., UI professor of internal medicine, was lead author of the paper, "Induction of Inflammasome Dependent Pyroptosis by Carbon Black Nanoparticles," which outlined the results.
Monick said researchers expected to find one level of inflammation when cells were exposed to carbon black nanoparticles. They were surprised, however, to find that nanoparticles activated a special inflammatory process and killed cells in a way that further increased inflammation. She said the research showed that the intake of carbon black nanoparticles from sources such as diesel fuel or printer ink caused an initial inflammatory response in lung cells. The surprising results came when the team discovered that these nanoparticles killed macrophages -- immune cells in the lungs responsible for cleaning up and attacking infections -- in a way that also increases inflammation.
"Apoptosis is one way cells die in which all the contents stay in the cell, the cell just keeps shrinking onto itself and the surrounding tissue is protected," Monick said. "We thought that was what was happening with the carbon nanoparticles; we were wrong. A different process called pyroptosis was occurring, causing the cells to burst and spill their contents."
That, she said, can cause a secondary inflammatory response.
Monick cautioned that the doses of carbon black nanoparticles used in the study were much more concentrated than the amounts to which a person might typically be exposed.
"This doesn't mean that walking through a cloud of diesel exhaust will hurt your lungs," she said. "It does show that we may have an environmental exposure that could contribute to inflammation in the lung."
The study was a collaborative project involving researchers in the Department of Internal Medicine in the UI Carver College of Medicine and the Department of Chemistry in the College of Liberal Arts and Sciences. In addition to Monick, a key contributor to the research was Vicki Grassian, Ph.D., UI professor of chemistry who holds the F. Wendell Miller Professorship.
The research team also included Anna C. Reisetter, Linda Powers, and Amit Gupta from internal medicine and Larissa V. Stebounova, and Jonas Baltrusaitis in chemistry.
The study was funded in part by a grant from the National Institutes of Health.
Source: University of Iowa /...
Previous Story: Improving Computer Memory with Nanowire Measurements
Next Story: How Does the UK Close the Skills Gap?
The Institute of Nanotechnology puts significant effort into ensuring that the information provided on its news pages is accurate and up-to-date. However, we cannot guarantee absolute accuracy. Consequently, the Institute of Nanotechnology disclaims any and all responsibility for inaccuracy, omission or any kind of deficiency in relation to the news items and articles hosted herein.
- 25 November 2013Nanomedical Device and Systems Design: Challenges, Possibilities, Visions
- 01 November 2013NanoSafety Cluster Launches its first newsletter
- 14 October 2013Developing EU–Latin America Nanotech Cooperation - the NMP–DeLA project kicks off
- 24 September 2013Should We Use Nanotechnology to Feed Ourselves?
- 18 September 2013UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles
- View All