3D Microfluidic mixer by Femtosecond Laser Direct Writing
Microfluidics is a rapidly emerging technology that enables miniaturization and integration for biological, chemical, and medical applications. The fluid mixing is an essential function required by most microfluidic systems, however, fast and efficient fluid mixing inside microchannels is usually difficult to achieve due to the laminar nature of microflows characterized by low Reynolds numbers. Recently, various passive mixers have been developed to achieve efficient mixing by utilizing three-dimensional (3D) geometric structures to induce disturbance in the fluids. Nevertheless, the fabrication of 3D microfluidic structures with arbitrary geometries is still challenging if not impossible, because today’s mainstream microfluidic fabrication techniques heavily rely on the well-established 2D planar lithographic approach.
Researchers at State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences (SIOM, CAS) developed a new technique to fabricate microchannels in glass with nearly unlimited lengths and with arbitrary geometries. The main fabrication process includes two steps: (1) direct formation of hollow microchannels in a mesoporous glass substrate immersed in water by femtosecond laser ablation; and (2) postannealing of the glass substrate at 1150℃. This consolidates the nanoscale pores by causing them to collapse. However, the fabricated microchannels survive due to their larger size. Based on this newly established technique, a passive microfluidic mixer consisted of geometrically complex 3D microchannels was demonstrated, as illustrated in Figure 1a. The superior mixing efficiency of the 3D mixer is also confirmed by numerical simulations as well as mixing experiments, as shown in Figures 1b and 1c, respectively.
The dimensions of channel can be easily changed by controlling the machining parameters, such as the numerical aperture of objective, the laser pulse energy and the translation speed. To show this capability, a 3D microfluidic lantern composed of 3D microchannels with different sizes was fabricated by this technique. When either fluorescein sodium solution or Rhodamine B solution was injected into the microchannel and excited by a laser operated at 490nm or 540nm wavelengths, the lantern produced either green or red colors, as shown in Figures 1d and 1e, respectively.
The Institute of Nanotechnology puts significant effort into ensuring that the information provided on its news pages is accurate and up-to-date. However, we cannot guarantee absolute accuracy. Consequently, the Institute of Nanotechnology disclaims any and all responsibility for inaccuracy, omission or any kind of deficiency in relation to the news items and articles hosted herein.
- 25 November 2013Nanomedical Device and Systems Design: Challenges, Possibilities, Visions
- 01 November 2013NanoSafety Cluster Launches its first newsletter
- 14 October 2013Developing EU–Latin America Nanotech Cooperation - the NMP–DeLA project kicks off
- 24 September 2013Should We Use Nanotechnology to Feed Ourselves?
- 18 September 2013UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles
- View All