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14 June 2012 NanoValid

2nd NanoValid Newsletter
Image Credit: NanoValid.

The members of the consortium recently met again in Copenhagen (8-9 May 2012) to discuss the progress of work and critical tasks and questions, such as the set up of various inter-laboratory studies (round robins) and their integration and synchronization with other projects (in particular with EU FP7 MARINA and QNano), or the design and creation of a common web-based data platform to continuously collect, quality control and validate the increasingly generated new scientific data, and how to harmonize the format of this research database with the planned central Nanosafety cluster knowledge and data hub.

During the first 6 months, work has mainly focused on the selection of a first set of test materials and a first round of preliminary testing and characterization has been implemented. Two prototypes of meso-porous silica from our industrial partner Nanologica AB, and 1 prototype of silver from the MARINA industrial partner Colorobbia, have been selected and tested so far, after an intensive discussion both internally and with MARINA experts. The first results have been produced by using different methods, such as XRD, DLS, Z-pot, TEM, SEM, BET and ICP, and the data discussed by the various experts during the Copenhagen meeting, to assess their comparability and accuracy, also in relation to material fabrication, sample preparation and measurement/instrument conditions. In a next step, a 2nd set of test materials has been selected and will be characterized by a 2nd round of measurement and testing, including another prototype of silver, as well as Au, CNTs and coated and uncoated TiO2. In addition, a protocol on dispersion control will be developed together with partners from MARINA, and the characterized test materials exposed to different test media, to see how properties and exposure/effects may change, and to arrive at a good reproducibility and stability of the selected nanomaterials in the various test media. In addition, further inter-laboratory comparison studies (round robins) are planned with MARINA and QNano, including the validation of methods for physicochemical characterization, for in vivo and in vitro human toxicology testing,and for NP labelling (see pages 2, 5 and 7).

The urgent need and demand for highly validated scientific data on the physicochemical properties, hazard and exposure of market-relevant nanomaterials sharply contrasts the high speed by which these and new next generation nanomaterials are manufactured and introduced to the market, which in turn emphasizes again the need to validate the methods we use to reliably characterize these novel materials, and to identify and uncover key mechanisms and factors that steer the interactions between their unique surface properties and possible impacts on human health and the environment.

With this in mind, it becomes evident how important it is for decision and policy makers to find practical ways (i.e. criteria and guidelines to ensure the safety and sustainability of nanomaterials) to rapidly and intelligently use and translate the knowledge we produce into the safe design, manufacture, use and disposal of newly fabricated nanomaterials.

This 2nd NanoValid Newsletter has again compiled a lot of new information to keep you up to date with relevant developments and events going on in the nanosafety research and application fields. On pages 4-9 you will find some exciting examples of the research our experts are conducting, followed by news from the Nanosafety cluster on page 10, including
the announcement of forthcoming meetings and events which you may find interesting (pages 11-13).

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Source: NanoValid /...

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